Category Archives: Neuroscience

Renewed Interested in Mind-Expanding Substances

mind expansionIf you were old enough to experience the cultural tides of the 1960s, you most certainly would have heard of Dr. Timothy Leary. He was the flamboyant Harvard professor whose research on psychedelics led him to believe that “the effects of consciousness expanding drugs will… transform our concepts of human nature, of human potential, of existence.” In that spirit, he also admonished America’s youth to: “Turn on. Tune in. Drop out.” Such commentary and the associated moral panic contributed to rendering all such drugs illegal in 1970.

That’s pretty much all I knew about psychedelics until I picked up Michael Pollan’s latest book, How To Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Addiction, Depression, and Transcendence. He serves up a modern history of these substances, a first-hand account of their use, and a bit of neuroscience to explain their effects.

Scientific research on psychedelics started in the mid-20th Century after a Swiss biochemist by the name of Albert Hoffmann synthesized LSD in 1938. He was searching for pharmaceutical relief for those with terminal illness or psychiatric disorders. His invention did not gain much traction until he took at second look at it in in 1943. He used himself as a test subject and realized that he had something very powerful on his hands. In 1958, he identified the active ingredient in psychedelic mushrooms (psilocybin) and devised a mechanism to synthesize it.

Psychedelics were used successfully in the 1950s and 1960s in controlled settings to treat addiction, depression, obsessive compulsive disorder, schizophrenia, autism, and end-of-life anxiety. Forty thousand people participated in clinic trials, and thousands of peer-reviewed scientific papers were published. Unfortunately, all of the countercultural baggage associated with psychedelics put the kibosh on funded laboratory research.

For the next 25 years, psychedelic experimentation went underground. A dedicated group of practitioners continued to deploy these substances to help their patients. They acknowledged the importance of “set and setting” in delivering experiences that would prove forwarding. They knew that psychedelics had expectancy effects – i.e., one tended to have the experience for which one was primed. As such, patients had to be screened carefully, and trained guides needed to provide suitable instructions prior to administering the drug. Treatment rooms were appropriately pleasing with soothing sights, sounds, and smells abounding. And patients were told that they would not be left unattended during any part of their experience.

While many practitioners focused on attending to persons with physical or psychological challenges, another collective conducted experiments to measure the ways in which psychedelics might improve the lives of “healthy” individuals. Early research suggested the potential to transcend mental limitations and improve problem-solving skills. (Apparently, many Silicon Valley pioneers found this possibility compelling.) They could also become less judgmental, less rigid, more open, and less defended. Many participants reported that their use of mind-expanding substances occasioned mystical experiences for which there was sustained personal and spiritual significance.

In 2006, funded (legal) psychedelic research began anew to address intractable psychiatric problems for which the earlier research had shown promising results. These renewed efforts had the advantage of brain imaging technology that would enable neuroscientists to understand what was going on inside the brain during psychedelic trips. The results proved fascinating.

It turns out that our brains have what’s called a Default Mode Network (DMN) that sits atop the functional hierarchy of the brain. It filters incoming sensory data while coordinating signals across the brain regions. Formed in late child development, it is closely associated with our egos – who we believe ourselves to be, how we see ourselves in relation to the world, what we like/dislike, what we deem right/wrong, etc. While it gives us a sense of self, it also creates a sense of separation from others.

Test subjects demonstrate decreased blood flow (i.e., activity) in the DMN on psychedelics. When this part of the brain goes “off line,” a wholly new state of consciousness can emerge – one that opens the floodgates to sensory data while diminishing boundaries between “ME” and everything else. It also creates the opportunity for the disparate brain regions to forge new connections. As Pollan says, when the “superhighways” in the brain stop working, the regions start using the old country back roads to communicate. Lasting change can occur when exercising these new connections after the fact.

So why have these drugs been effective for treating folks in challenging circumstances? An overactive DMN can trap people in an endless loop of rumination. Breaking that cycle can provide relief. For example, patients with terminal illness can break free of their anxiety, depression, and “Why Me?” thoughts and focus on a heightened sense of connection with loved ones. Persons suffering with depression can experience relief from the mental prison that renders feelings of disconnection. Addicts may see the world as offering so many wonders that they’ll forgo destructive behaviors that rob them of exploring these possibilities.

As an interesting aside, highly experienced mediators generate states of consciousness (as measured by brain scans) that bear a striking resemblance to persons on psychedelic drugs. It’s yet another argument for finding a comfortable lotus position and developing this skill.

Pollan does a yeoman’s job describing the erstwhile indescribable feeling of being under the influence of a psychedelic substance. As one who went into the experience with a healthy dose of skepticism (and trepidation), he gives the experience its due without underselling or overblowing its merits. Suffice it to say, it piqued my interest.

Is Play Necessary?

polar bear and dog playIn the far Northern reaches, a group of sled dogs gain a much-needed rest from their master. Off in the distance, a hungry polar bear approaches, causing great alarm among the pack and their master. When the bear arrives, the lead dog signals the intent to play, and the bear goes along. Threat averted!

Play is pervasive in the animal kingdom. Yet it’s incredible to think that the desire for play can take precedence over the survival instinct. After all, to the casual observer, play is a seemingly purposeless expenditure of time that provides a pleasant diversion from the ordinary business of life. But the impulse to play is a biological drive. And as Dr. Stuart Brown details in Play: How It Shapes the Brain, Opens the Imagination, and Integrates the Soul, play has been proven scientifically to be an incredibly useful activity.

Our brains self-create as a function of the environments in which they operate and the experiences they amass. Play stimulates secretion of brain-derived neurotropic factors (BDNF) that the brain uses to build and maintain its cellular circuitry. BDNF improves neural function and helps enrich and shape neural connections. Play also helps the brain gain experience in contrived settings that can be deployed in real life circumstances – e.g., practicing karate with friends at a dojo that can be used if and when a physical threat arises. And, of course, play provides a low-risk setting to discover and cultivate all those wonderful skills.

Play optimizes the mind-set to improve alertness, attention, and motivation. Transforming a learning experience from rote memorization to a playful game vastly improves engagement in the moment and retention after the fact. The more experimentation with the “game,” the greater the comprehension of how the subject matter at hand works.

Play confers skills that bolster emotional intelligence. Players learn how to cooperate, how to navigate difference, and how to establish and maintain trust. They also learn how to discern who has their backs and who is gunning for them. Belonging is an outgrowth of social play.

Play is essential for aging gracefully. Studies consistently link favorable health outcomes with adults who continue to explore, play games, and learn throughout their lives. They’re not only less susceptible to dementia, they’re less likely to suffer from heart disease and other ailments seemingly unrelated to the brain.

Play and work are mutually supportive. In both, we learn new things, exercise our creativity, develop our skills, forge relationships, stretch ourselves, and achieve goals. Play helps us cope with work-related stress and personal difficulties while providing a sense of expansiveness that allows for clear thinking. It can provide the space for the critical insight that solves a problem or illuminates an opportunity. And, as Dr. Brown notes, “true play that comes from our own inner needs and desires is the only path to finding lasting joy and satisfaction in our work.”

How Do We Get Rid of Bad Habits?

Popular software programs provide a feature that enables users to capture programming sequences that they use habitually. It saves time and improves accuracy on repetitive tasks.

As it turns out, our brains have a similar mechanism. It manages this function in our behalf automatically. In fact, a 2006 study by Duke University revealed that 40% of our daily activities take advantage of these stored sub-routines. Charles Duhigg explores this fascinating subject in his book in The Power of Habit: Why We Do What We Do in Life and Business.

The brain’s basal ganglia provide the means to capture and store patterns of behavior, a process referred to as “chunking.” When chunks combine to form habits, our brains can process other thoughts, or simply enjoy a quiet moment.

Other members of the animal kingdom form habits. In fact, they’ve helped researchers figure out how habits work.

For example, scientists measured brain activity in rats as they learned to navigate a maze in search of cheese. During the learning phase, brain activity remained high from the time they entered the maze (their behavioral “cues”) until they reached their rewards (cheese). Once they’d mastered the routine, brain patterns were only elevated when encountering the initial cue and when reaping the fruits – or should I say, cheese – of their labors.

brain activity and habit formation

Of course, we don’t lock in on every pattern of behavior in which we’ve engaged. The reward must be sufficiently compelling to fuel anticipation for it. Craving powers the habit loop.

Once we’ve learned a habit, it remains in our memory banks indefinitely… or, at least, a really, really long time. Unfortunately, our brains don’t discern between “good habits” and “bad habits.” Even when we work hard at bypassing the latter, “bad habits” can re-emerge at any time.

So how can we reset our wiring so that we don’t get tripped up by our “bad habits”?

First and foremost, we need to amp up our awareness so that we don’t get caught operating on autopilot. We need to identify our “cues” – that is, the triggers that cause us to launch our bad habit loops. We also need to get crystal clear on the rewards that fuel these loops.

For example, suppose I find that I consistently break away from my home office at 3 pm to watch a little TV and nosh on whatever happens to be readily available in the refrigerator. I’d ask myself: What’s really going on at 3 pm that triggers this behavior? Am I bored? Fatigued? Restless? Tapped out? What payoff am I getting from watching TV? Am I simply looking for a way to give my mind a break? Or do I really think that I’m getting some form of creative input by my daily dose of Netflix? Moreover: Am I really hungry, or am I simply finding another avenue to relieve boredom?

After getting a handle on the cues (triggers) and cravings for reward, it’s easier to think creatively about launching different routines. For example, if my 3 pm date with the TV and the refrigerator reflects a need to take and break and clear my mind, I could simply take a short walk with my dog when the urge strikes.

Duhigg describes the Gold Rule of Habit Change as follows: Keep an old cue, deliver an old reward, but insert a new routine. A “competing response” disrupts an old habit. However, a new routine can only replace the old one when it is accompanied by faith that it will work – that is, faith that things will get better, and faith in one’s coping mechanisms when facing temptation, discomfort, or suffering.

When substantive lifestyle changes are at stake, it’s helpful to identify and strengthen keystone habits. When these habits shift, they have the power to dislodge and remake other patterns. For example, the keystone habit of regular exercise tends to make people eat better, smoke less, improve sleep patterns, experience higher productivity, and feel less stress. It creates a structure in which other forwarding habits flourish while delivering a series of self-reinforcing “small wins.”

Within the realm of keystone habits, willpower reigns supreme. Strengthen willpower in one area of your life, and you reap benefits in others. The bad news: Willpower is a bit like a muscle that can get fatigued by excess use. The good news: It is aided and abetted by tactics that conserve its energy – e.g., removing temptations, drawing attention away from triggers, consistently focusing on the prize.

Finally, as social creatures, we’re often helped (or sabotaged) by the company we keep. We increase our odds of success by placing ourselves within communities that support and reinforce habits that we hope to manifest every day.

The Biology of Behavior

Most of us like to think that we’re in complete control of our actions. We picture ourselves as rational beings capable of making the right choices at the right times for the right reasons. But as Dr. Jonathan Sapolsky writes in Behave: The Biology of Humans and Our Best and Worst, many factors influence the biology of behavior, some of which operate below conscious awareness.

Sensory input impacts our thought processes. For example, if we’re cradling a warm drink, we think warm thoughts about others. By contrast, cold drinks elicit a more frosty assessment. And if we’re in pain (or even really hungry), we’re more apt to be aggressive.

bad or good behaviorRapid response brain regions impact our decisions and behaviors. The amygdala perceives sensory data through the lens of fear, uncertainty, and doubt. It evokes action to keep us from harm’s way and injects distrust and vigilance into decision processes. The hippocampus provides assistance by retaining information related to amygdala activity, thereby speeding response the next go around. They’re great defenders for real and present dangers; they’re troublesome for recovery from ingrained prejudice or past trauma (e.g., PTSD).

Hormones affect our perceptions and behaviors. For example, testosterone has been correlated with confidence, optimism, and aggression while decreasing fear and anxiety.

Neuropeptides (oxytocin and vasopressin) promote pair bonding and stimulate paternal/maternal behavior. While they elicit charitable behavior toward other members of our group, they increase aggression toward strangers when protecting loved ones.

The dopaminergic system regulates the pleasure center. In a healthy individual, it confers a sense of satisfaction in goal-directed behavior that anticipates future reward. Unfortunately, over-to-top sources of reward (e.g., sugar, alcohol, drugs, gambling) engender cravings, addiction, and habituation. The more we take in, the more we want.

The frontal cortex provides cognition, working memory, emotional regulation, rational decision making, and long-term planning. It’s the area of the brain that is least influenced by genetic inheritance and most sculpted by experience. It has the capacity to interpret sensory and emotional inputs and modulate our responses. For example, amygdaloidal neurons may fire in response to perceived threat, but the frontal cortex has veto power if it thinks the stimulus isn’t scary. That being said, the amygdala tends to carry the day for split second decision making; the frontal cortex requires deliberation.

As cognitive load on the frontal cortex increases, people become less empathetic, charitable, and honest. They’re more likely to succumb to temptation or make rash decisions. Habit formation proves an effective counterweight. It reduces cognitive load by rendering behaviors automatic. Other tactics for avoiding temptation include distraction (drawing one’s mind away from the stimulus) and reappraisal (changing the narrative of what’s happening in the moment). By contrast, good old fashioned willpower increases cognitive load.

Finally, culture exerts a profound impact on how we think and behave. Collectivist cultures emphasize harmony, interdependence, and conformity; individualist cultures stress autonomy, personal achievement, and individual rights. Stratified cultures (e.g., unequal incomes) foster more violence and less trust and kindness. Urban dwellers tend to have more reactive amygdalas, causing heightened fear and anxiety.

The biology of US versus THEM struck me as one of the more fascinating topics in Dr. Sapolsky’s book. We are biologically wired to process differences in race, ethnicity, gender, social status, and beauty. Our brains are especially attuned to skin color. We form US-THEM dichotomies within milliseconds of exposure to other human beings. Dress, ornamentation, and regional accent augment the visual cues as markers of values, beliefs, and ideologies. We feel a sense of obligation and reciprocity toward those we deem part of US, and we’re more likely make amends to those within our group. THEY can be viewed as threatening, angry, and untrustworthy. THEY might even evoke disgust.

us versus themWe all belong to several US-THEM groupings, and our affiliations vary over time. Yet we do not need to be held hostage to our biological or cultural biases. If we acknowledge that factions exist, we can choose to follow our better angels. We can focus on larger, shared goals. We can invest the time and effort to “walk in someone else’s shoes” and see the world from a different vantage point. And we can stop, question, think, and reason when confronting engrained biases.

It takes more cognitive load to empathize with people with whom there is less common ground. Social competency demands more processing cycles in the frontal cortex. Yet sustained contact among groups decreases prejudice while increasing knowledge and empathy.

The good news: We make neurons throughout our lives, and our neurons regularly remap. So even old dogs can learn new tricks!

Sugar, Obesity, and the Brain

teaspoon of sugarI’ve written about sugar in earlier posts – notably, its effect on our physiology and its addictive power. I got another dose of admonitions against this pervasive component of the American diet when reading Grain Brain: The Surprising Truth About Wheat, Carbs, and Sugar, Your Brain’s Silent Killers by Dr. David Permutter.

For most of human history, sugar made rare appearances in the diet. We simply didn’t have access to the raw materials or the technology to refine it. We only consumed a modest amount of fructose and glucose in fresh fruits and vegetables. So our bodies had to develop elaborate mechanisms to convert protein and fat to glucose and release it into the bloodstream.

Insulin provides the means to transport glucose from the bloodstream into muscle, fat, and the liver. Upon arrival, it is stored as a readily available source of fuel. However, once cells have their fill, they’ll grow insensitive to further attempts by insulin to “unlock their doors” and deposit additional glucose – a condition known as insulin resistance. Excess glucose molecules remain in the bloodstream and attach themselves to proteins, fats, and amino acids, a process called glycation. Once glycated, proteins don’t do their jobs well. Moreover, glycated proteins have been shown to create a 50-fold increase in free radical formation relative to proteins that are not glycated. Free radicals give rise to inflammation which, among other things, sparks arterial plaque formation. Plaque accumulation gives rise to coronary artery disease (CAD), Alzheimer’s disease, and stroke.

For most of us, excess weight is the only physical manifestation of too much sugar in the diet. We may find it bothersome that our clothes don’t fit as well or that we face the implied criticism from a culture that venerates thin people. But it turns out that when excess fat accumulates in adipose tissue, it’s anything but passive. Visceral fat (around the organs) secretes a large amount of cytokines that trigger inflammatory pathways. The refuse from our bodies’ immune response dumps into the liver. The liver then ups the ante on inflammatory and hormone-disrupting substances.

sugar and the brainIf the after-effects of inflammation fail to sound the alarm, perhaps loss of cognitive function might do the trick. Dr. Perlmutter notes that chronically obese individuals have been shown to have 8% less brain tissue than folks of normal weight. Chronically overweight individuals may experience a 4% drop in brain tissue. Much of this tissue loss occurs in the frontal or temporal lobe, the locus of executive decision making.

A change in diet lowers the risk of obesity, vascular disease, and inflammation linked to cognitive decline. Avoid foods and beverages responsible for the biggest surges in blood sugar – i.e., anything made with refined flour, starches (rice, potatoes, corn), liquid carbs (e.g., fruit juices, soft drinks), and, of course, added sugar, sugary sauces, and syrups. Get your carbs from whole fruits and vegetables. They’re bound up with insoluble fiber and water which slows fructose and glucose absorption to a rate the body can handle… in moderation.

Why Our Brains Are Not Computers

our brain is not a computerI used to think that our brains were like computers. After all, they process lots of input, use logic to make executive decisions, store and retrieve memories, and produce output. Yet after reading Welcome to Your Brain and watching Dr. Sam Wang’s 36-part DVD entitled Neuroscience of Everyday Life, I have a whole new perspective.

Our brains are not designed for pinpoint accuracy, like a computer. They’re in the business of keeping us alive. To that end, Dr. Wang tells us that “at any given moment, your brain is lying to you.” Here’s how…

The brain takes in huge amounts of information through its sensory processors – eyes, ears, nose, mouth, and skin. As it sifts through the input, it combines a lifetime of experience with its expectations to render judgments, store what’s useful, and discard what it deems unimportant. Speed takes precedence over accuracy.

Forty percent of our brain is sensitive to visual stimulation. A large number of brain regions can activate in response to visual signals without entering that input into consciousness. Conscious awareness may function like a spotlight that focuses on specific stimuli and ignores others. And by the time we’re cognizant of visual images, our brains have already made assumptions about what we’re looking at.

The brain’s mechanism for storing and retrieving memories also falls into the realm of not-at-all-like-a-computer. Memories get stored in shorthand based on what the brain considers important. There’s also good evidence that we erase and re-write our memories every time we recall them. And we invent details to fill in the gaps and create a more coherent story. Researchers have demonstrated this phenomenon in laboratory experiments. For example, they can show their subjects a list of words that share a consistent meaning – e.g., ice cream, honey, lollipop, sugar, candy, chocolate. When asked later if the word sweet was on the list, most folks say yes with confidence. They make a reasonable inference that the word made the list even though it did not.

The hippocampus serves as the initial repository for our memories. In the process of rewriting as we re-experience them, memories can change transition from the hippocampus to the neocortex. As this transfer occurs, some memories get separated from the context in which they occurred and get woven into the fabric of our general knowledge. For example, we’ll remember that Salem is the capital of Oregon, but we won’t recall when, where, or how we learned that fact. Dreams likely play an important role in memory consolidation.

Armed with this information, I’m more likely to adopt a generous response when others recount memories that are inconsistent with my recollection. I’ll also be wary of declaring that my historical narratives are factually true.

synaptic connectionsOur brains also play close attention to activity on all of its synaptic connections. It strengthens synapses that see frequent use (“cells that fire together, wire together”). This mechanism enables us to execute thousands of sequences in everyday life without having to think much about them (e.g., tying our shoe laces). It also weakens or removes synapses that remain dormant while others are actively used (“out of synch, lose you link”). This phenomenon is referred to as neural plasticity. It has several important practical applications:

  • If there’s a goal that you’d like to accomplish, visualize the process of attaining it in as much detail as possible and as often as possible. When your brain is wired for success, you’re far less likely to be stymied by roadblocks along the way.
  • When teaching a class, provide some initial exposure to key facts or conclusions. By preparing the brain for what’s ahead, it’s more likely to pay attention to specific pieces of information. For example, an early quiz sets the brain up for future learning.
  • If you need to study for an exam, break your preparation into several relatively small sessions (45-90 minutes). Your brain will retain information longer if it has the chance to process it between study sessions.
  • If something or someone makes you unhappy, find a way to distract yourself when the memory emerges. If you dwell on it, you simply reinforce the pain and increase the likelihood that it will keep popping up. Turn your attention to something pleasant.
  • Reappraisal is a powerful tool for transforming unhappy memories. Find a way to change the meaning of the event into something positive and forwarding. Folks skilled in reappraisal tend to be emotionally stable and resilient.

Finally, frequent small positive events have a greater cumulative effect on happiness than large positive events. For example, when people win the lottery, they typically go through an initial period of euphoria after which they revert to their former set points. To elevate your set point, eliminate daily irritants, set realistic goals and achieve them, use your character strengths, and cultivate a daily practice of gratitude.

Why Exercise is Good for the Brain

Most of us can recite the reasons why exercise is good for our bodies. Aerobic exercise strengthens our cardiovascular system and raises our metabolic rates. An elevated metabolism burns more calories which helps us maintain a healthy weight. Load-bearing exercise (a.k.a. “pumping iron”) builds muscles and strengthens bones. And a daily dose of vigorous exercise can help us sleep better at night. In SPARK: The Revolutionary New Science of Exercise and the Brain, Dr. John J. Ratey, MD gives us yet another reason to move. Exercise gets our brains to function at peak efficiency.

ready to learnTwo innovative school districts served as “demonstration plots” for the mind-body connection in active fitness programs. Teachers reported that when students in the Naperville IL or Titusville PA school districts completed a mile run:

  • They went to class alert, focused, and ready to learn.
  • They were less fidgety, tense, and moody.
  • They felt more motivated and invigorated.
  • They outperformed peers who did not participate in a fitness regimen.

The last point merits special attention. Naperville’s District 203 students placed among the highest echelons of students academically in the U.S. and abroad. Some dismissed these results given Naperville’s favorable socioeconomic standing (although District 203 compared favorably to schools with comparable demographics). Titusville serves an underprivileged population. Their students went from below average performance statewide to 17% above average in reading and 18% above average in math. Moreover, they experienced a near absence of fist fights. Both districts also reported very low rates of childhood obesity.

For the record, Physical Education (PE) at Naperville and Titusville isn’t the “stand around and wait your turn to bat a ball” kind of fitness. Nor is it a one-size-fits-all program. Kids are encouraged to find an activity they enjoy with the right level of effort to elevate their heart rates to their target zones. If kids like wall climbing, they climb walls (and enjoy their classmates’ cheers and encouragement while doing it). If they’re slow runners but manage to get their heart rates up, they’ll receive praise for working at their own paces.

The other end of the age spectrum also provides “demonstration plots.” Among elderly populations, those who are educated, confident in their ability to effect positive change (a.k.a. “self-efficacious”), and exercised exhibit the least cognition decline.

From this launching pad, Dr. Ratey’s book dives into the neuroscience behind the beneficial impact of exercise. Here’s a high-level summary:

  • Exercise elevates neurotransmitters (serotonin, norepinephrine, and dopamine) responsible for attention, perception, motivation, arousal, and mood.
  • Exercise elevates brain derived neurotropic factors (BDNF) that build and maintain brain circuitry. It strengthens our cellular machinery for learning.
  • Cells sprouted during exercise increase the attraction between neurons and their likelihood to “spark” (a.k.a., long term potentiation or LTP).
  • The most effective form of aerobic exercise calls upon the brain to acquire skills while we move. For example, partner dancing forces the brain to take another person into account. Aerobic classes that change up the patterns of movements also encourage “skill” development.
  • The mild stress of exercise activates genes that produce proteins to protect our brain cells against damage and disease.
  • The heart muscle secrets ANP during exercise which travels through the blood-brain barrier to create a calming effect. It’s an antidote for anxiety and panic attacks.
  • exercise is good for the brainWhile exercise and medication are both effective at treating depression, consistent exercise works better over the long run. In fact, a Duke University study found that every 50-minute installment of weekly exercise reduces the odds of being depressed by 50%.
  • Exercise tricks the brain into maintaining itself for survival despite the hormonal cues that it is aging.

Dr. Ratey’s anti-aging prescription for exercise: 60 minutes of aerobic exercise at least 4x per week; strength training at least 2x per week to build strong bones and ward off osteoporosis; and, 30 minutes of flexibility and balance exercise 2x per week. It may seem rather daunting, but your body and your brain will love you for it!